c57bl 6 Search Results


organisms  (ATCC)
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ATCC organisms
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old  (Inotiv)
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c57bl  (Jackson Laboratory)
86
Jackson Laboratory c57bl
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c57bl 6 mice envigo rrid mgi  (Jackson Laboratory)
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c57bl 6 mice  (Envigo)
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female c57bl 6n mice aged 9  (Envigo)
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c57bl  (Envigo)
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southern biotech cat 5300 05b  (SouthernBiotech)
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SouthernBiotech southern biotech cat 5300 05b
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dy1857 05 sba clonotyping system c57bl  (SouthernBiotech)
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isotype  (SouthernBiotech)
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splenocytes  (iQ Biosciences)
94
iQ Biosciences splenocytes
NG-ISACs activate myeloid and lymphoid cells independent of ADCC and ADCP. A, FcγR-mediated activation was assessed using Jurkat-Lucia NFAT-CD16 and NFAT-CD32 reporter cells cocultured with CFPAC-1 tumor cells. ISAC-induced NFAT signaling was measured by Lucia luciferase activity 6 hours after incubation. Glycosylated ISACs are shown with dashed lines whereas NG-ISACs are shown with solid lines. B and C, Mouse BMDM-M2 ( B ) and <t>splenocytes</t> ( C ) were stimulated with E104 for 24 hours, followed by analysis of IL6 production using ELISA. D and E, RAW-Dual reporter macrophages were cocultured with BxPC-3‒TROP2 high ( D ) or CFPAC-1‒TROP2 medium tumor cells ( E ) in the presence of NG-ISACs or controls. Activation of NF-κB signaling pathways was measured. H, Mouse BMDM-M2 cells were cocultured with BxPC-3‒TROP2 high tumor cells and stimulated with NG-ISACs for 24 hours. IL6 production was quantified by ELISA. I, Mouse splenocytes were cocultured with hTROP2-expressing tumor cells and stimulated with NG-ISACs for 24 hours. IL6 production was quantified by ELISA. Data are presented as the mean ± SD ( n = 3), and EC 50 values are from three independent experiments. OD, optical density; RLU, relative light units.
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mouse sinusoidal endothelial cells  (AcceGen Biotechnology)
93
AcceGen Biotechnology mouse sinusoidal endothelial cells
NG-ISACs activate myeloid and lymphoid cells independent of ADCC and ADCP. A, FcγR-mediated activation was assessed using Jurkat-Lucia NFAT-CD16 and NFAT-CD32 reporter cells cocultured with CFPAC-1 tumor cells. ISAC-induced NFAT signaling was measured by Lucia luciferase activity 6 hours after incubation. Glycosylated ISACs are shown with dashed lines whereas NG-ISACs are shown with solid lines. B and C, Mouse BMDM-M2 ( B ) and <t>splenocytes</t> ( C ) were stimulated with E104 for 24 hours, followed by analysis of IL6 production using ELISA. D and E, RAW-Dual reporter macrophages were cocultured with BxPC-3‒TROP2 high ( D ) or CFPAC-1‒TROP2 medium tumor cells ( E ) in the presence of NG-ISACs or controls. Activation of NF-κB signaling pathways was measured. H, Mouse BMDM-M2 cells were cocultured with BxPC-3‒TROP2 high tumor cells and stimulated with NG-ISACs for 24 hours. IL6 production was quantified by ELISA. I, Mouse splenocytes were cocultured with hTROP2-expressing tumor cells and stimulated with NG-ISACs for 24 hours. IL6 production was quantified by ELISA. Data are presented as the mean ± SD ( n = 3), and EC 50 values are from three independent experiments. OD, optical density; RLU, relative light units.
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Image Search Results


NG-ISACs activate myeloid and lymphoid cells independent of ADCC and ADCP. A, FcγR-mediated activation was assessed using Jurkat-Lucia NFAT-CD16 and NFAT-CD32 reporter cells cocultured with CFPAC-1 tumor cells. ISAC-induced NFAT signaling was measured by Lucia luciferase activity 6 hours after incubation. Glycosylated ISACs are shown with dashed lines whereas NG-ISACs are shown with solid lines. B and C, Mouse BMDM-M2 ( B ) and splenocytes ( C ) were stimulated with E104 for 24 hours, followed by analysis of IL6 production using ELISA. D and E, RAW-Dual reporter macrophages were cocultured with BxPC-3‒TROP2 high ( D ) or CFPAC-1‒TROP2 medium tumor cells ( E ) in the presence of NG-ISACs or controls. Activation of NF-κB signaling pathways was measured. H, Mouse BMDM-M2 cells were cocultured with BxPC-3‒TROP2 high tumor cells and stimulated with NG-ISACs for 24 hours. IL6 production was quantified by ELISA. I, Mouse splenocytes were cocultured with hTROP2-expressing tumor cells and stimulated with NG-ISACs for 24 hours. IL6 production was quantified by ELISA. Data are presented as the mean ± SD ( n = 3), and EC 50 values are from three independent experiments. OD, optical density; RLU, relative light units.

Journal: Molecular Cancer Therapeutics

Article Title: Nonglycosylated, Legumain-Cleavable ISACs Drive Potent Antitumor Immunotherapy via a Bystander Effect

doi: 10.1158/1535-7163.MCT-25-1153

Figure Lengend Snippet: NG-ISACs activate myeloid and lymphoid cells independent of ADCC and ADCP. A, FcγR-mediated activation was assessed using Jurkat-Lucia NFAT-CD16 and NFAT-CD32 reporter cells cocultured with CFPAC-1 tumor cells. ISAC-induced NFAT signaling was measured by Lucia luciferase activity 6 hours after incubation. Glycosylated ISACs are shown with dashed lines whereas NG-ISACs are shown with solid lines. B and C, Mouse BMDM-M2 ( B ) and splenocytes ( C ) were stimulated with E104 for 24 hours, followed by analysis of IL6 production using ELISA. D and E, RAW-Dual reporter macrophages were cocultured with BxPC-3‒TROP2 high ( D ) or CFPAC-1‒TROP2 medium tumor cells ( E ) in the presence of NG-ISACs or controls. Activation of NF-κB signaling pathways was measured. H, Mouse BMDM-M2 cells were cocultured with BxPC-3‒TROP2 high tumor cells and stimulated with NG-ISACs for 24 hours. IL6 production was quantified by ELISA. I, Mouse splenocytes were cocultured with hTROP2-expressing tumor cells and stimulated with NG-ISACs for 24 hours. IL6 production was quantified by ELISA. Data are presented as the mean ± SD ( n = 3), and EC 50 values are from three independent experiments. OD, optical density; RLU, relative light units.

Article Snippet: Ramos-Blue reporter cells (2024, InvivoGen, cat. #rms-sp, RRID: CVCL_X591), human peripheral blood mononuclear cells (PBMC; male; iXCells Biotechnologies, November of 2024), mouse BMDM-M2 and splenocytes (March 2024; iQ Biosciences; female, IQB-MSP202), BxPC-3 cells (2023, ATCC, cat. #CRL-1687, RRID: CVCL_0186), RAW-Dual reporter cells (May 2019, InvivoGen, cat. #rawd-ismip, RRID: CVCL_A7ZK), MC38-hTROP2 (April 2024, Kyinno Biotechnology, cat. #KC-1698), Jurkat-Lucia NFAT-CD16 (June 2024, InvivoGen, cat. #jkt-nfat-cd16, RRID: CVCL_A7ZT), and NFAT-CD32 (August 2024, InvivoGen, cat. #jkt-nfat-cd32, RRID: CVCL_A7ZU) were also obtained.

Techniques: Activation Assay, Luciferase, Activity Assay, Incubation, Enzyme-linked Immunosorbent Assay, Protein-Protein interactions, Expressing